KNPE 493 – Special Topic: Advanced Protein Metabolism
The aim of my research program is to understand the cellular and molecular mechanisms underpinning the adaptive response of skeletal muscle to nutrition, exercise training, and immobilization. I specialize in the use of stable isotopic tracers to track skeletal muscle protein turnover combined with a variety of molecular biology techniques for measurement of enzyme activity, protein expression, and post-translational modification.
Graduate Student Opportunities
Prospective students are strongly encouraged to apply for scholarships and awards offered through the TriCouncil CGSM Master’s Award – National Sciences and Engineering Research Council of Canada (NSERC); other external agencies that provide funding to graduate students; and the Ontario Graduate Scholarship (OGS). Deadlines for these competitions generally fall in October — several months before the deadlines for our graduate programs. Only students who have already applied for funding from these external agencies will be eligible for the various internal fellowships and awards offered by Queen’s University to incoming students.
McGlory C, Gorissen SHM, Kamal M, Bahniwal R, Hector AJ, Baker SK, Chabowski A, Phillips SM. Omega-3 fatty acid supplementation attenuates skeletal-muscle-disuse-atrophy during two weeks of unilateral leg immobilization in healthy young women. FASEB J. 2019 Mar;33(3): 4586-4597. doi:10.1096fj.201801857RRR.
McGlory C, von Allmen MT, Stokes T, Morton RG, Hector AJ, Lago BA, Raphenya AR, Smith BK, McArthur AG, Steinberg GR, Baker SK, Phillips SM. Failed recovery of glycemic control and myofibrillar protein synthesis with two weeks of physical inactivity in overweight, pre-diabetic older adults. J Gerontol A Biol Sci Med Sci. 2018 Jul 9;73(8):1070-1077. doi: 10.1093/gerona/glx203.
McGlory C, Calder PC, Nunes EA. The influence of omega-3 fatty acids on skeletal muscle protein turnover in health, disuse, and disease. Front Nutr. 2019 Sep 6;6:144. doi: 10.3389/fnut.2019.00144.
McGlory C, van Vliet S, Stokes T, Mittendorfer B, Phillips SM. The impact of exercise and nutrition in the regulation of skeletal muscle mass. J Physiol. 2018 Jul 16. doi: 10.1113/JP275443
Phillips SM, McGlory C. Rebuttal from Stuart M. Phillips and Chris McGlory. J Physiol. 2014 Dec 15;592(24):5349. doi: 10.1113/jphysiol.2014.284406.
Phillips SM, McGlory C. CrossTalk proposal: The dominant mechanism causing disuse muscle atrophy is decreased protein synthesis. J Physiol. 2014 Dec 15;592(24):5341-3. doi: 10.1113/jphysiol.2014.273615.
Miotto PM, McGlory C, Bahniwal R, Kamal M, Phillips SM, Holloway GP. Supplementation with dietary ω-3 mitigates immobilization-induced reductions in skeletal muscle mitochondrial respiration in young women. FASEB J. 2019 Jul;33(7):8232-8240. doi: 10.1096/fj.201900095R.
McGlory C, Wardle SL, Macnaughton LS, Witard OC, Scott F, Dick J, Bell JG, Phillips SM, Galloway SD, Hamilton DL, Tipton KD. Fish oil supplementation suppresses resistance exercise and feeding-induced increases in anabolic signaling without affecting myofibrillar protein synthesis in young men. Physiol Rep. 2016 Mar;4(6). pii: e12715. doi: 10.14814/phy2.12715.
McGlory C, Galloway SD, Hamilton DL, McClintock C, Breen L, Dick JR, Bell JG, Tipton KD. Temporal changes in human skeletal muscle and blood lipid composition with fish oil supplementation. Prostaglandins Leukot Essent Fatty Acids. 2014 Jun;90(6):199-206. doi: 10.1016/j.plefa.2014.03.001.
McGlory C, White A, Treins C, Drust B, Close GL, Maclaren DP, Campbell IT, Philp A, Schenk S, Morton JP, Hamilton DL. Application of the [γ-32P] ATP kinase assay to study anabolic signaling in human skeletal muscle. J Appl Physiol. (1985). 2014 Mar 1;116(5):504-13. doi: 10.1152/japplphysiol.01072.2013.